PTCB PTCE Practice Test Questions Answers

Tetracyclines, includingdoxycycline and minocycline, are broad-spectrum antibiotics used to treat bacterial infections. They have amajor drug-drug interaction with calcium-containing antacidsand other minerals.

Chelation Effect:Calcium binds to tetracycline, forminginsoluble complexesthat prevent the antibiotic from being absorbed in thegastrointestinal (GI) tract.

Reduced Efficacy:Because the drug cannot be absorbed, the antibiotic’s effectiveness is significantly reduced.

Similar Interactions:Magnesium, iron, and aluminum (found in many antacids, dairy products, and multivitamins) also reduce tetracycline absorption.

Take on an Empty Stomach(1 hour before or 2 hours after meals).

Avoid Dairy, Antacids, and Multivitaminsfor at least2 hours before and aftertaking tetracycline.

Drink with a Full Glass of Waterto prevent esophageal irritation.

B. Decongestants that contain pseudoephedrine.→ Incorrect. Pseudoephedrine does not interact with tetracycline.

C. Antitussives that contain dextromethorphan.→ Incorrect. Dextromethorphan does not affect tetracycline absorption.

D. Analgesics that contain acetaminophen.→ Incorrect. Acetaminophen does not bind to tetracycline or impact its absorption.

Lexicomp Drug Interaction Database – Tetracycline and Calcium Interactions.

FDA Drug Label for Tetracycline – Absorption and Drug Interaction Warnings.

Mosby’s Pharmacy Technician: Principles and Practice – Tetracycline Pharmacology.

PTCB PTCE Exam Content Outline – Drug Interactions and Contraindications.

Why Should Tetracycline Not Be Taken with Calcium-Containing Antacids?Patient Counseling for Tetracycline Use:Why the Other Answer Choices Are Incorrect:Pharmacy Technician References:

Phenobarbital is abarbiturateused forseizure control, sedation, and epilepsy management. It is commercially available in both:

Oral tablet form(commonly used for long-term seizure control).

Injectable solution form(used in hospital settings for status epilepticus and acute seizure episodes).

B. Paroxetine❌→Available only as oral tablets and oral suspension.

C. Pioglitazone❌→Available only as oral tablets (for diabetes management).

D. Pramipexole❌→Available only as oral tablets (for Parkinson’s disease and restless legs syndrome).

FDA Drug Labeling Database– ListsPhenobarbital as available in oral and injection forms.

American Society of Health-System Pharmacists (ASHP) Drug Database– Confirmsinjectable and oral availability of Phenobarbital.

PTCB PTCE Exam Content Outline– Covers medication dosage forms and routes of administration.

Why Not the Other Options?Key References:

TheFDA classifies recalls into three levels, withClass III being the least severe:

Class I Recall→Most severe→ Issued when a drugmay cause serious harm or death.

Class II Recall→Moderate severity→ The drug may causetemporary or medically reversible adverse effects.

Class III Recall→Least severe→ The productis unlikely to cause harm but violates FDA regulations(e.g., labeling errors, minor packaging issues).

A. Is issued when there is a reasonable probability that the product will cause serious adverse health consequences or death.❌→Incorrect

Describes a Class I recall, not Class III.

B. Is initiated by the FDA if a manufacturer has violated the adulteration provisions of the Food, Drug, and Cosmetic Act (FDCA).❌→Incorrect

FDA action due to adulteration typically leads to Class I or Class II recalls, depending on severity.

C. Occurs when a product may cause temporary or medically reversible adverse health consequences.❌→Incorrect

Describes a Class II recall, not Class III.

FDA Drug Recall Guidelines– Defines Class I, II, and III recalls.

PTCB PTCE Exam Content Outline– Covers recall classifications and pharmacy responsibilities.

FDA Enforcement Report– Lists real-world examples of Class III recalls (e.g.,mislabeling, incorrect expiration dates).

Why Not the Other Options?Key References:

The abbreviation"PO"means"by mouth" (per os).

The abbreviation"ac"stands for"before meals" (ante cibum).

The phrase"daily for 14 days"indicates that the patient should take the medication once a day for a total of 14 days.

Thus, the correct label instructions should be:"Take one capsule by mouth before a meal once daily for 14 days."

PTCB PTCE Exam Content Outline – Prescription Interpretation– Covers standard medical abbreviations.

ISMP (Institute for Safe Medication Practices) List of Common Pharmacy Abbreviations– Defines "PO" (by mouth) and "ac" (before meals).

USP Medication Labeling Standards– Ensures clear and accurate patient instructions.

Pharmacy Technician References:

Alot numberis a unique identifier assigned to a specific batch of a medication during manufacturing.

TheNational Drug Code (NDC)andserial numberare different from the lot number.

On medication stock bottles, the lot number is often preceded by"(10)", which is present in this case:

(10)ABC123→This represents the lot number.

B. 55555444422→ This appears to be aGTIN (Global Trade Item Number), which identifies the product but is not the lot number.

C. 051526→ This could represent a manufacturer’s internal code or part of the packaging details, but not the lot number.

D. 11262026→ This follows the(21) identifier, which represents theexpiration date (November 26, 2026).

PTCB PTCE Exam Content Outline – Medication Labeling and Lot Numbers

FDA Drug Supply Chain Security Act (DSCSA)– Provides guidance on tracking drug batches.

USP Chapter <1079> Good Storage and Distribution Practices– Covers stock bottle labeling and identification.

Why Other Answers Are Incorrect?Pharmacy Technician References: