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FPGEE NABP Foreign Pharmacy Graduate Equivalency Examination Free Practice Exam Questions (2025 Updated)

Prepare effectively for your NABP FPGEE Foreign Pharmacy Graduate Equivalency Examination certification with our extensive collection of free, high-quality practice questions. Each question is designed to mirror the actual exam format and objectives, complete with comprehensive answers and detailed explanations. Our materials are regularly updated for 2025, ensuring you have the most current resources to build confidence and succeed on your first attempt.

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Total 426 questions

Which of the following causes the smallest change in solubility?

A.

Hydroxylation

B.

Glucuronidation

C.

Sulfation

D.

Glutathione conjugation

Mechanism of action of cefoxitin is:

A.

monoamine reuptake inhibitor

B.

Inhibits cholesterol synthesis

C.

Inhibits activation of GPIIb/IIIa

D.

Inhibits transpeptidase

E.

Inhibits Na-K-2Cl transporter

Contraindication of sulfamethoxazole is:

A.

Gout

B.

Diabetes mellitus

C.

Hyperlipidemia

D.

Liver disease

E.

Late pregnancy

Effect of bisacodyl is:

A.

Decreases total cholesterol by 8-12%

B.

Decreases water absorption

C.

Decreases total cholesterol by 20-50%

D.

Enhances mucociliary clearance

E.

Decreases triglycerides by 10-20%

Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given in the previous question is entirely hepatic clearance.

A.

30 L/hr/70 Kg

B.

60 L/hr/70 Kg

C.

120 L/hr/70 Kg

D.

250 L/hr/70 Kg

Mechanism of action of isoetharine is:

A.

Inhibits phosphodiesterase

B.

Reduces calcium influx into neurons

C.

Potentiates glucose-mediated insulin secretion

D.

Inhibits phospholipase A2

E.

beta-2 agonist

Which of the following is not directly related to a drug toxicity of Nitroglycerin?

A.

Headaches

B.

Tachycardia

C.

Dizziness

D.

Projectile vomiting

Which of the following statements refers to HPMPC?

A.

Tricyclic.

B.

Cytosine monophosphate analog

C.

Works by accumulating in and changing pH of lysosomes.

D.

Mild intrinsic sympathomimetic activity - does not decrease heart rate and contractility as much during exercise.

E.

Metabolized in liver by P450.

Class of pyrimethamine is:

A.

Antifolates

B.

Antivirals

C.

Aquaretics

D.

Autonomic nervous system drugs

E.

H2 antagonists

Route of excretion of cinoxacin is:

A.

Unknown

B.

Kidneys

C.

Intestines

D.

Liver

Which of the following statements refers to etidronate?

A.

Binds to DNA, preferentially to GC pairs. Inhibits RNA, DNA, and protein synthesis.

B.

Human, pig, salmon, and eel calcitonins are available.

C.

Is used for both therapy and prophylaxis of influenza A.

D.

Bioavailability increases with administered dose.

E.

Only approved by FDA for hypertension treatment.

Indication of doxycycline is:

A.

Bacteroides (other than Bacteroides fragilis)

B.

Asthma

C.

Meniere's disease

D.

Water intoxication

E.

Broad spectrum antibacterial agent

Mechanism of resistance of dicloxacillin is:

A.

Decreased drug uptake by bacteria

B.

Mutations in M (matrix) protein

C.

Beta-lactamase

D.

Penicillin binding proteins (PBPs)

E.

Antibodies resulting from streptococcal infection

Class of cilastin is:

A.

Azoles

B.

ACE inhibitors

C.

Retinoids

D.

Dehydropeptidase I inhibitors

E.

K sparing diuretics

Indication of salmeterol is:

A.

Thyrotoxicosis - preparation for surgery

B.

Chronic renal disease

C.

Scleroderma renal crisis

D.

Asthma

E.

Allergic rhinitis

Which of the following is considered a class IA Sodium Channel blocker?

A.

Propafenone

B.

Disopyramide

C.

Aminodarone

D.

Quinidine

Which of the following statements refers to phenelzine?

A.

Mechanism of action probably involves NO.

B.

Rapid IV infusion predisposes to neuromuscular paralysis.

C.

May work when other antidepressants fail.

D.

Long half-life.

E.

MOA is inhibited irreversibly. Response occurs when >80% platelet MOA is inhibited.

Mechanism of action of ampicillin is:

A.

Inhibits cholesterol synthesis

B.

Inhibits transpeptidase

C.

Inhibits viral DNA polymerase

D.

Potentiates glucose-mediated insulin secretion

E.

Inhibits renal epithelial Na channels

Side effect of actinomycin D is:

A.

Bronchospasm

B.

Hypotension

C.

GI toxicity

D.

Oral and GI ulcers

E.

Dysphonia

Which of the following enzymes could metabolize ethanol?

A.

Cytochrome P450

B.

Alcohol Dehydrogenase

C.

Glucuronyl Transferase

D.

Sulfotransferase

E.

All of the above

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Total 426 questions
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